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Symbol
Name
ID 		App
amyloid beta precursor protein
MGI:88059
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Cerebellar hemorrhage
Recurrent cerebral hemorrhage
Subarachnoid hemorrhage
Tortuous cerebral arteries
Stroke
Neurofibrillary tangles
Alzheimer disease
Parkinsonism
Long-tract signs
Dementia
Paresthesia
Disease(s) Associated with APP
Alzheimer's disease 1
APP-related cerebral amyloid angiopathy

Mouse Phenotypes
nervous system phenotype
decreased susceptibility to pharmacologically induced seizures
increased susceptibility to pharmacologically induced seizures
seizures
clonic seizures
myoclonus
tonic-clonic seizures
intracerebral hemorrhage
increased neuron apoptosis
decreased olfactory sensory neuron number
abnormal microglial cell morphology
microgliosis
amyloid beta deposits
CNS inflammation
abnormal brain morphology
decreased brain weight
abnormal brain commissure morphology
decreased corpus callosum size
absent corpus callosum
decreased hippocampal commissure size
decreased anterior commissure size
abnormal dentate gyrus morphology
hippocampal neuron degeneration
abnormal telencephalon morphology
abnormal stratification in cerebral cortex
neurofibrillary tangles
abnormal astrocyte morphology
astrocytosis
gliosis
abnormal neuron morphology
abnormal axon initial segment morphology
abnormal synapse morphology
neuron degeneration
neurodegeneration
axon degeneration
abnormal nervous system physiology
abnormal axonal transport
abnormal olfactory sensory neuron physiology
abnormal excitatory postsynaptic currents
abnormal long-term potentiation
reduced long-term potentiation
Availability Mouse Genotype
Apptm1.1Wevn/Apptm1.1Wevn
Apptm1.2Tlyp/Apptm1.2Tlyp *
Apptm1Ck/Apptm1Ck
Apptm1Cwe/Apptm1Cwe *! ! ! !
Apptm1Dbo/Apptm1Dbo
Apptm1Somm/Apptm1Somm
Apptm1Tsuz/Apptm1Tsuz *
Apptm2.1Ldad/Apptm2.1Ldad *
Apptm2.1Tcs/Apptm2.1Tcs
Apptm2Cwe/Apptm2Cwe ! ! !
Apptm2Umu/Apptm2Umu *
Apptm3.1Tcs/Apptm3.1Tcs
Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
Apptm1Ini/App+
Apptm3.2Umu/Apptm2Cwe
Tg(APP-App*R609D*K612E)7Vln/0
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)Dbo/0
Tg(Gng8-tTA)#Ryba/0
Tg(tetO-APPSwInd)Dbo/0
Tg(tetO-APPSwInd)Dbo/0
Tg(Thy1-App*R609D*K612E)2Vln/0
Tg(Thy1-App*R609D*K612E)4Vln/0
Tg(Thy1-App*R609D*K612E)6Vln/0
Tg(App)1874Kha/?
Apptm1.1Tlyp/Apptm1.1Tlyp
Tg(CAG-cre/Esr1*)5Amc/?  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory